The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology signs vasculitis complications msk extraarticular manifestations psoriaticarthritis ra rheumatoidarthritis temporal adhesivecapsulitis agammaglobulinemia ankylosingspondylitis bakerscyst benign bph centralretinalartery chondrocalcinosis comparison
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
Disease • Swelling ... Swollen Joints • Inflammation ... in Rheumatoid arthritis ... mild synovial inflammation ... JointDisease #JointPain #Diagnosis
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations Risk Factors: - Unclear environmental triggers (may be viral, not
Cell (Temporal) Arteritis ... mutation) that alter inflammatory ... old; F>M Signs/Symptoms ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
Rheumatoid arthritis ... Eyes: • Globe inflammation ... interstitial lung disease ... pathophysiology #signs #symptoms ... #diagnosis #ExtraArticular
Reactive Arthritis • Inflammation of joints (commonly large joints) - Asymmetric Oligoarthritis: Joint
Reactive Arthritis ... • Inflammation ... Effusions • Inflammation ... pathophysiology #diagnosis ... #signs #symptoms
Psoriatic Arthritis: Pathogenesis and Clinical findings In tendons and connective tissues: • Enthesitis - Pain/tenderness over
Psoriatic Arthritis ... • Dactylitis - Inflammation ... Arthritis of DIP ... pathophysiology #diagnosis ... #signs #symptoms
Psoriatic Arthritis: Complications • Ocular - Inflammation of middle layer of the eye (the uvea, which
Psoriatic Arthritis ... Cardiac - Valvular disease ... - Inflammatory ... pathophysiology #diagnosis ... #signs #symptoms
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
mellitus, thyroid disease ... shoulder joint inflammation ... as post-inflammatory ... pathophysiology #diagnosis ... #symptoms #signs
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... scaling that extend inflammation ... -> Incr local inflammation ... pathophysiology #diagnosis ... #signs #symptoms
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
Rheumatoid arthritis ... Pathogenesis and Joint diseases ... • Rate of inflammatory ... etc • Systemic inflammation ... #diagnosis
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
other autoimmune diseases ... with systemic diseases ... like rheumatoid arthritis ... Pathophysiology #Diagnosis ... #Signs #Symptoms
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