The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology diagnosis acute ophthalmology lupus manifestations otitismedia sle urology achilles adhesivecapsulitis anaphylaxis ankylosingspondylitis anterior benign bph bulimianervosa caudaequina centralretinalartery cholesteatoma
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
Anaphylaxis: Signs ... Signs / Symptoms ... / Complications ... pathophysiology #immunology ... #diagnosis #signs
Femoral Head Fracture: Pathogenesis and clinical findings • Posterior hip dislocation -> Impaction force from femoral
onto lateral hip Signs ... /Symptoms/Complications ... FemoralHead #Fractures #msk ... pathophysiology #signs ... #symptoms #orthopedics
Achilles Tendon Rupture - Pathogenesis and clinical findings • The Achilles tendon is 15cm long in
pre-determined etiology Signs ... /Symptoms/Complications ... TendonRupture #diagnosis #signs ... #symptoms #pathophysiology ... #msk #orthopedics
Stress Fracture: Pathogenesis and clinical findings Abnormal biomechanics, Repetitive impact activities => Repetitive subthreshold mechanical loading => Bone strain =>
StressFractures #msk ... #orthopedics #pathophysiology ... #symptoms #signs
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
cytokines -> localized inflammatory ... scaling that extend inflammation ... -> Incr local inflammation ... pathophysiology #diagnosis #signs ... #symptoms #complications
Acute Otitis Media: Complications Infection and inflammation of the middle ear - Prolonged obstruction of e. tube
Infection and inflammation ... becomes more severe Signs ... /Symptoms/Complications ... pathophysiology #symptoms ... #signs #diagnosis
Retinoblastoma: Pathogenesis and clinical findings • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Retinoblastoma Signs ... / Symptoms / Complications ... reflex) • Orbital inflammation ... ophthalmology #diagnosis #signs ... #symptoms
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Erythematosus #SLE #MSK ... Musculoskeletal #Complications ... pathophysiology #signs ... #symptoms #diagnosis
Acute Rheumatic Fever: Pathogenesis and Clinical Findings Delayed autoimmune reaction -> Molecular mimicry -> GAS antigen cross-reacts with host ->
Tissue injury and inflammation ... pathophysiology #diagnosis #signs ... #symptoms #complications
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
lumbar spine Signs ... / Symptoms / Complications ... CaudaEquina #Syndrome #MSK ... pathophysiology #diagnosis #symptoms ... #signs
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