The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
degranulation, leading ... to an allergic ... Sensitization" to Allergen ... Initial exposure to allergen ... #Immunology #pathophysiology
Patellofemoral Syndrome - Pathogenesis and clinical findings
 • Anterior Knee Pain with possible symptoms of 'catching'
clinical findings • Anterior ... pain • Palpable grinding ... Patellofemoral #Syndrome #pathophysiology ... #diagnosis #signs ... #symptoms #msk
Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
subthreshold mechanical loading ... from continued loading ... StressFractures #msk ... #orthopedics #pathophysiology ... #symptoms #signs
Anterior Shoulder Dislocation: Pathogenesis, clinical, and radiographic findings

Trauma, Fall on, outstretched arm, Overhead throwing => Abduction
Anterior Shoulder ... • Humeral head anterior ... Dislocation #Diagnosis #signs ... #symptoms #msk ... #orthopedics #pathophysiology
Low Ankle Sprain: Pathomechanics and Clinical Findings

Grading Ligament Sprains
l: Minimal ligament disruption, mild swelling & tenderness,
Clinical Findings Grading ... ligament substance leading ... LowAnkleSprain #Sports #MSK ... #orthopedics #Grading ... Grades #Diagnosis #pathophysiology
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
femoral head onto anterior ... onto lateral hip Signs ... FemoralHead #Fractures #msk ... #diagnosis #pathophysiology ... #signs #symptoms
Cubital Tunnel Syndrome: Pathogenesis and clinical findings

 • Paresthesia of 5th and medial half of 4th
test • + Tinel sign ... • + Froment's sign ... Syndrome #Diagnosis #pathophysiology ... #signs #symptoms ... #msk
Radiculopathy: Signs and Symptoms
 • Back/Neck Pain
 • Decr Range of motion
 • Abnormal posturing
 •
Radiculopathy: Signs ... pain Lasegue's sign ... Radiculopathy #MSK ... #diagnosis #signs ... #symptoms #pathophysiology
Spondylolysis & Spondylolisthesis: Pathogenesis and Clinical Findings

Pars interarticularis stress fracture (spondylolysis) - most frequently in the
XR — scotty dog sign ... Spondylolisthesis #MSK ... #diagnosis #pathophysiology ... #signs #symptoms
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications
 • Anterior Posterior Compression (APC) -
Complications • Anterior ... Anterior Sl diastasis ... Classification #Grades #Grading ... #Orthopedics #MSK ... complications #pathophysiology