The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Disc Herniations - Pathogenesis and Complications
• 90% of Lumbar disc herniations happen at L4/5 and L5/S1
•
-> Mechanical loading ... #DiscHerniations ... complications #msk ... #pathophysiology
Low Ankle Sprain: Pathomechanics and Clinical Findings

Grading Ligament Sprains
l: Minimal ligament disruption, mild swelling & tenderness,
Clinical Findings Grading ... ligament substance leading ... LowAnkleSprain #Sports #MSK ... #orthopedics #Grading ... Grades #Diagnosis #pathophysiology
Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
subthreshold mechanical loading ... from continued loading ... StressFractures #msk ... #orthopedics #pathophysiology
Patellofemoral Syndrome - Pathogenesis and clinical findings
 • Anterior Knee Pain with possible symptoms of 'catching'
pain • Palpable grinding ... Patellofemoral #Syndrome #pathophysiology ... signs #symptoms #msk
Alcohol Use Disorder: Pathogenesis and Clinical Findings

 • Tolerance (reduced sensitivity to effects of EtOH)
 •
- Alcohol craving ... AlcoholUseDisorder #EtOH #Pathophysiology ... Signs #Symptoms #Psychiatry
Bipolar Disorder: Pathogenesis and Clinical Findings
 • Disruption of emotional homeostasis
 • Oscillation between mood states
distractibility - racing ... MoodDisorders #Diagnosis #Pathophysiology ... Signs #Symptoms #Psychiatry
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications
 • Anterior Posterior Compression (APC) -
Classification #Grades #Grading ... #Orthopedics #MSK ... complications #pathophysiology
Anorexia Nervosa: Complications
CARDIAC ABNORMALITIES
 - Functional: Low BP, Sinus bradycardia, prolonged QT interval
 - Structural: Reduced
mortality rates of all psychiatric ... binge-purge subtype #AnorexiaNervosa ... Complications #pathophysiology ... signs #symptoms #psychiatry
Anorexia Nervosa: Pathogenesis and Risk Factors
Biological Risk Factors
 • Gender: F > M
 • Genetics: concordance
athletics) #AnorexiaNervosa ... #pathophysiology ... signs #symptoms #psychiatry
Anorexia Nervosa: Signs and Symptoms
Binge/Purge Subtype - Recurrent (once per week) episodes of binge-eating or purging,
irritability #AnorexiaNervosa ... #pathophysiology ... signs #symptoms #psychiatry