The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis symptoms sle adhesivecapsulitis caudaequina differential diffuse dupuytrens erythematosus frozenshoulder lfcn manifestations meralgiaparesthetica mucocutaneous musculoskeletal pagetsdisease scleroderma stages syndrome systemic
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Erythematosus #SLE #MSK ... Musculoskeletal #Complications ... #pathophysiology ... #signs #symptoms
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Subacute cutaneous lupus ... Manifestations #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
lumbar spine Signs ... / Symptoms / Complications ... pain (shooting, stabbing ... CaudaEquina #Syndrome #MSK ... #pathophysiology
Meralgia paresthetica: Pathogenesis and Clinical Findings Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica •
intervertebral disc disease ... , Stabbing) - ... MeralgiaParesthetica #MSK ... #pathophysiology ... differential #diagnosis #signs
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings • Primary (Idiopathic): Unknown etiology, but associated
mellitus, thyroid disease ... FrozenShoulder #pathophysiology ... diagnosis #symptoms #signs ... #stages #staging ... #msk
Dupuytren’s Disease: Pathogenesis and Clinical Findings • Aging, smoking and/or diabetes -> Microangiopathy and palmar fascia
Dupuytren’s Disease ... Clinical Findings • Aging ... #Contractures # ... pathophysiology ... #msk
Diffuse Systemic Sclerosis (Scleroderma) - Pulmonary Fibrosis -> Crackles, Abnormal CXR - Pulmonary Hypertension, Right Heart
Renal Failure - Mask ... (i.e. a "purse-string ... Finger/hand/elbow contractures ... #Scleroderma #pathophysiology ... #signs #symptoms
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Paget’s Disease: ... Complications ... bone formation MSK ... PagetsDisease #pathophysiology ... #diagnosis #signs
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