The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Pathogenesis of Anxiety Disorders

Anxiety Disorders: A maladaptive emotional state causing fear,
worry, and excessive stress, characterized by:
Pathogenesis of Anxiety ... Disorders Anxiety ... Disorders: A maladaptive ... #Disorders #Pathophysiology ... #diagnosis #psychiatry
Post-Traumatic Stress Disorder (PTSD)
Neurochemical abnormalities
 • Hyper-vigilance
 • Emotional hyper-arousal
 • Exaggerated startle reflex
 • Anxiety
Post-Traumatic Stress Disorder ... startle reflex • Anxiety ... BehavioralDisorder #Pathophysiology ... symptoms #signs #psychiatry
Obsessive-Compulsive Disorder (OCD): Pathogenesis and clinical findings

Psychological Hypothesis
 • Cognitive behavioral model: Emotional disturbance arising from
Obsessive-Compulsive Disorder ... maladaptive beliefs and anxiety ... Dysregulation of anxiety ... Obsessive-Compulsive Disorder ... PersonalityDisorder #Diagnosis #Psychiatry
Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings

Symptoms (included in DSM 5 criteria) - Present during
Major Depressive Disorder ... Seasonal Affective Disorder ... partum onset) - Anxiety ... MoodDisorders #Diagnosis #Pathophysiology ... Signs #Symptoms #Psychiatry
Bipolar Disorder: Pathogenesis and Clinical Findings
 • Disruption of emotional homeostasis
 • Oscillation between mood states
Bipolar Disorder ... - Incr guilt, anxiety ... behaviours #Bipolar #Disorder ... MoodDisorders #Diagnosis #Pathophysiology ... Signs #Symptoms #Psychiatry
Alcohol Use Disorder: Pathogenesis and Clinical Findings

 • Tolerance (reduced sensitivity to effects of EtOH)
 •
Alcohol Use Disorder ... , seizure, and anxiety ... AlcoholUseDisorder #EtOH #Pathophysiology ... Signs #Symptoms #Psychiatry
Major Depressive Disorder: Complications
 • Recurrent Depressive Episodes
 • Early parenthood
 • Social isolation and interpersonal
Major Depressive Disorder ... dependence • Anxiety ... Disorder • Educational ... Complications #Pathophysiology ... #Psychiatry
Schizotypal Personality Disorder (SPD): Pathogenesis and clinical findings
Cognitive-Perceptual
 • Magical thinking - Belief in paranormal or
Schizotypal Personality Disorder ... anhedonia • Social Anxiety ... reference - Anxiety ... developmental disorders ... PersonalityDisorder #Diagnosis #Psychiatry
Systemic Lupus Erythematosus: Gastrointestinal Manifestations
 - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Vasculitis -> Acute ... Esophageal Motility Disorders ... Complications #pathophysiology
Panic Disorder: Pathogenesis and clinical findings
Social Factors
 • Parenting and infant attachment
 • Childhood illness/abuse
 •
Panic Disorder: ... heritability >> Panic Disorder ... carrying anti-anxiety ... BehavioralDisorder #Pathophysiology ... symptoms #signs #psychiatry