The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Pathogenesis of Anxiety Disorders

Anxiety Disorders: A maladaptive emotional state causing fear,
worry, and excessive stress, characterized by:
Pathogenesis of Anxiety ... Disorders Anxiety ... acid (GABA) #Anxiety ... #Disorders #Pathophysiology ... #diagnosis #psychiatry
Post-Traumatic Stress Disorder (PTSD)
Neurochemical abnormalities
 • Hyper-vigilance
 • Emotional hyper-arousal
 • Exaggerated startle reflex
 • Anxiety
startle reflex • Anxiety ... BehavioralDisorder #Pathophysiology ... symptoms #signs #psychiatry
Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings

Symptoms (included in DSM 5 criteria) - Present during
partum onset) - Anxiety ... MoodDisorders #Diagnosis #Pathophysiology ... Signs #Symptoms #Psychiatry
Alcohol Use Disorder: Pathogenesis and Clinical Findings

 • Tolerance (reduced sensitivity to effects of EtOH)
 •
, seizure, and anxiety ... AlcoholUseDisorder #EtOH #Pathophysiology ... Signs #Symptoms #Psychiatry
Bipolar Disorder: Pathogenesis and Clinical Findings
 • Disruption of emotional homeostasis
 • Oscillation between mood states
- Incr guilt, anxiety ... MoodDisorders #Diagnosis #Pathophysiology ... Signs #Symptoms #Psychiatry
Panic Disorder: Pathogenesis and clinical findings
Social Factors
 • Parenting and infant attachment
 • Childhood illness/abuse
 •
carrying anti-anxiety ... Anticipatory Anxiety ... PanicDisorder #Anxiety ... BehavioralDisorder #Pathophysiology ... symptoms #signs #psychiatry
Major Depressive Disorder: Complications
 • Recurrent Depressive Episodes
 • Early parenthood
 • Social isolation and interpersonal
dependence • Anxiety ... Complications #Pathophysiology ... #Psychiatry
Social Anxiety Disorder (SAD) - Pathophysiology 
Excessive fear of one or more social situations
 • Safety
Social Anxiety Disorder ... (SAD) - Pathophysiology ... reduce social anxiety ... BehavioralDisorder #SAD #Pathophysiology ... symptoms #signs #psychiatry
Pediatric Parasomnias and Nightmares: Pathogenesis and clinical findings

Parasomnias - Micro-arousal episodes during SWS ->
Intense activation of
system -> • Fear/anxiety ... Nightmares #Pediatrics #Peds ... #pathophysiology
Anorexia Nervosa: Pathogenesis and Risk Factors
Biological Risk Factors
 • Gender: F > M
 • Genetics: concordance
Temperament: childhood anxiety ... AnorexiaNervosa #pathophysiology ... signs #symptoms #psychiatry