The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
Thyroid gland hyperplasia ... etiology Signs/Symptoms ... GravesDisease #pathophysiology ... endocrinology #symptoms
Antisocial Personality Disorder (ASPD): Pathogenesis and Clinical Findings
Work & lnterpersonal:
 • Home Life Troubles - Conflict
Antisocial Personality ... disorder #ASPD #Antisocial ... #PersonalityDisorder ... Criteria #Signs #Symptoms
Dependent Personality Disorder (DPD): Pathogenesis and Clinical Findings
 • Difficulties with Activities - Initiation Of projects
Dependent Personality ... self #DPD #Dependent ... #PersonalityDisorder ... Criteria #Signs #Symptoms
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings

Hormonal alterations (result of aging process)
    ->
Benign Prostatic Hyperplasia ... of ER and AR -dependent ... Benign #Prostatic #Hyperplasia ... #Prostate #Pathophysiology ... Urology #Signs #Symptoms
Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Syndrome Signs/Symptoms ... Complications: • Gonadal hypoplasia ... Syndrome #genetics #pathophysiology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
congenital adrenal hyperplasia ... Signs/Symptoms/Complications ... #21HydroxylaseDeficiency #21OHD #pathophysiology
Opioid Withdrawal: Clinical Findings and Complications
Note: Opioid withdrawal can be extremely uncomfortable, but is rarely life-threatening
varies depending ... Symptoms can take ... The somatic symptoms ... • Somatic Symptoms ... Withdrawal #Opiate #Pathophysiology
Conduct Disorder (CD): Pathogenesis and clinical findings
 - Must have >3 symptoms present in the past
- Must have >3 symptoms ... months, with >1 symptom ... past 6 months - Symptoms ... not be met for antisocial ... BehavioralDisorder #Pathophysiology
Seasonal Affective Disorder: Pathogenesis and clinical findings

Symptoms (included in the DSM-V) - Two Major Depressive episodes
clinical findings Symptoms ... Hypersomnia - Hyperphagia ... season at work) Symptoms ... MoodDisorders #Diagnosis #Pathophysiology ... #Signs #Symptoms
Charcot Joint - Neuropathic Arthropathy: Pathogenesis and Clinical findings
 • Impaired joint protection -> abnormal joint
pain (variable dependent ... #Arthropathy #pathophysiology ... diagnosis #signs #symptoms