The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology complications sle erythematosus ra rheumatoidarthritis systemic ankylosingspondylitis arteritis avascularnecrosis gastrointestinal msk mucocutaneous musculoskeletal pan polyarteritisnodosa takayasus
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Gastrointestinal Manifestations ... the pancreas, Vasculitis ... -> Acute Pancreatitis ... pathophysiology #signs ... #symptoms #diagnosis
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Manifestations ... Livedo Reticularis, Vasculitis ... Mucocutaneous #Manifestations ... pathophysiology #diagnosis ... #signs #symptoms
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Musculoskeletal Manifestations ... #Systemic #Lupus ... pathophysiology #signs ... #symptoms #diagnosis
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
Extra-articular manifestations ... blood vessels (vasculitis ... pathophysiology #signs ... #symptoms #diagnosis ... #ExtraArticular
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings Medical Comorbidities Malignancies (most commonly hairy-cell leukemia) Immunogenetic Predisposition: patient is
swelling - GI Manifestations ... Pathophysiology #Diagnosis ... #Signs #Symptoms ... #Vasculitis
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
Extra-articular manifestations ... • Non-specific Acute-phase ... Extra-articular signs ... pathophysiology #signs ... #symptoms #diagnosis
Ankylosing Spondylitis: Extra-articular Manifestations • Ocular - Inflammation of the iris, the anterior part of the
Extra-articular Manifestations ... - Inflammation acute ... AnkylosingSpondylitis #Extraarticular ... pathophysiology #diagnosis ... #signs #symptoms
Avascular Necrosis: Pathogenesis and Clinical Findings • Physical Trauma (esp. to the scaphoid bone with damage
therapy - Lupus ... affected) - Acute ... hypolucency "Crescent sign ... pathophysiology #diagnosis ... #signs #symptoms
Takayasu’s Arteritis: Pathogenesis and clinical findings - Fatigue, weight loss, low grade fever, arthralgias - Incr
, Incr risk of Acute ... Takayasus #Arteritis #Vasculitis ... #Diagnosis #Signs ... #Symptoms
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