The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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pathophysiology signs symptoms complications erythematosus lupus ra rheumatoidarthritis sle allergic allergy causes classification comparison definitions degenerative extraarticular femoralhead fractures gait
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... - Arthralgia, Arthritis ... Osteonecrosis Esp ... Erythematosus #SLE #MSK ... signs #symptoms #diagnosis
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... the pancreas, Vasculitis ... - Budd Chiari Syndrome ... distension #Systemic ... signs #symptoms #diagnosis
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
IgA Vasculitis – ... nephrotic/nephritic syndrome ... Arthralgia's (common), arthritis ... and ankles) #HSP ... Pathophysiology #Diagnosis
Trendelenburg Gait: Pathogenesis and clinical findings Skeletal Pathology of the Hip • Arthritis • Congenital hip dysplasia
Pathology of the Hip ... • Arthritis ... • Congenital hip ... symptoms #signs #diagnosis ... #msk
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
Primary Sjogren’s Syndrome ... (PBC), or with systemic ... like rheumatoid arthritis ... (RA) or systemic ... Pathophysiology #Diagnosis
Femoral Head Fracture: Pathogenesis and clinical findings • Posterior hip dislocation -> Impaction force from femoral
• Posterior hip ... wall • Anterior hip ... weight-bear • Arthritic ... FemoralHead #Fractures #msk ... #diagnosis #pathophysiology
Takayasu’s Arteritis: Pathogenesis and clinical findings - Fatigue, weight loss, low grade fever, arthralgias - Incr
Takayasu’s Arteritis ... Acute Coronary Syndrome ... - >10mmHg systolic ... #Takayasus #Arteritis ... #Vasculitis #Diagnosis
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
Rheumatoid arthritis ... Inflammation of skin (esp ... blood vessels (vasculitis ... blood to limbs (esp ... signs #symptoms #diagnosis
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
complexes • Ex: Systemic ... Erythematosus, Reactive Arthritis ... Stevens-Johnson Syndrome ... Classification #Diagnosis
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
is oftentimes systemic ... in Rheumatoid arthritis ... affects the knee hip ... Comparison #Versus #MSK ... JointDisease #JointPain #Diagnosis
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