The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
Graves’ Disease: ... the etiology Signs ... pathophysiology #endocin #endocrinology ... #symptoms #signs ... #diagnosis
Meralgia paresthetica: Pathogenesis and Clinical Findings
Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica
 •
sensory • Before diagnosis ... intervertebral disc disease ... MeralgiaParesthetica #MSK ... #differential #diagnosis ... #signs #symptoms
Pseudogout: pathogenesis and clinical findings
 - Idiopathic (vast majority of cases) -> Mechanism unknown
 - Familial
pyrophosphate dihydrate (CPPD ... and/or x-ray - CPPD ... #Disease #Signs ... #Symptoms #Pathophysiology ... #Diagnosis
Paget’s Disease: Pathogenesis and Clinical Findings

 • Incr serum CTx - marker of bone resorption
 •
Paget’s Disease: ... formation #PagetsDisease ... pathophysiology #diagnosis ... #signs #symptoms
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
Cardiovascular disease ... Overproduction #diagnosis ... #signs #symptoms ... #endocrinology
Chondrocalcinosis: Calcium Pyrophosphate Dihydrate (CPPD) Deposition Disease

 - Acute CPPD precipitation into the joint space ->
) Deposition Disease ... - Acute CPPD ... #Disease #Signs ... #Symptoms #Pathophysiology ... #Diagnosis
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
Injury #Syndromes #diagnosis ... pathophysiology #signs ... #symptoms #msk ... #orthopedics #neurology
Scoliosis: Pathogenesis and clinical findings (Cobb Angle > 10 Degrees)

 • Incr Axial rotation of thoracic
Restrictive Pulmonary Disease ... pathophysiology #msk ... #diagnosis #signs ... #symptoms
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings

 • Primary (Idiopathic): Unknown etiology, but associated
mellitus, thyroid disease ... pathophysiology #diagnosis ... #symptoms #signs ... stages #staging #msk
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Paget’s Disease: ... bone formation MSK ... hearing loss #PagetsDisease ... pathophysiology #diagnosis ... #signs #symptoms