The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings

Hormonal alterations (result of aging process)
    ->
Benign Prostatic ... to ERs in the prostate ... Inflammation: Incr tissue injury ... chronic renal injury ... Pathophysiology #Urology
Benign Prostatic Hyperplasia: Pathogenesis and Medications
Aging
 -> Increased Testosterone -> Testosterone metabolized into DHT by type
Benign Prostatic ... a-reductase in prostate ... Hyperplasia of the prostate ... -> Prostate encapsulated ... #Pharmacology #Urology
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
below level of injury ... spinal artery injury ... below level of injury ... tumour causing injury ... #orthopedics #neurology
Lower Urinary Tract Infections: Complications
 - Infection damages the urinary tract epithelium causing fibroblast proliferation and
urethra travel to prostate ... via prostatic ducts
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
cells -> Tissue injury ... Pancarditis and valvular injury
Myelopathy - Injury to the entire spinal cord - Signs and Symptoms
 • Ataxia (early sign)
Myelopathy - Injury
Low Ankle Sprain: Pathomechanics and Clinical Findings

Grading Ligament Sprains
l: Minimal ligament disruption, mild swelling & tenderness,
most commonly injured ... the CFL is also injured ... (uncommonly injured ... PTFL is rarely injured
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications
 • Anterior Posterior Compression (APC) -
possible vascular injury ... - Type 1 or 2 injury
Open Fractures: Mechanisms, Clinical Features and Complications
Gustilo-Anderson Classification:
 • Type I
   - Wound <
Typically "inside out" injury
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
Avulsion or shearing injury