The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Myopathy (Also caused ... #Complications ... #pathophysiology ... #signs #symptoms ... #diagnosis
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
/Symptoms/Complications ... FemoralHead #Fractures #msk ... #diagnosis #pathophysiology ... #signs #symptoms ... #orthopedics
Achilles Tendon Rupture - Pathogenesis and clinical findings
 • The Achilles tendon is 15cm long in
/Symptoms/Complications ... TendonRupture #diagnosis ... #signs #symptoms ... #pathophysiology ... #msk #orthopedics
Cauda Equina Syndrome
Causes:
 • Large lumbar degenerative disc herniation (central)
 • Severe lumbar spondylosis
 • Neoplasm
Equina Syndrome Causes ... / Symptoms / Complications ... CaudaEquina #Syndrome #MSK ... #pathophysiology ... #diagnosis #symptoms
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications
 • Anterior Posterior Compression (APC) -
Clinical Features and Complications ... Grades #Grading #Orthopedics ... #MSK #diagnosis ... #complications ... #pathophysiology
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... hair follicles -> causes ... Manifestations #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
Injury #Syndromes #diagnosis ... #pathophysiology ... #signs #symptoms ... #msk #orthopedics ... #neurology
Mixed Urinary Incontinence: Pathogenesis and Clinical Findings

Urgency Urinary Incontinence (UUI) -> Urinary leakage preceded by a
Incr PVR if a complication ... SUI or UUI not caused ... Incontinence #Mixed #Pathophysiology ... #Signs #Symptoms ... #Urology #Diagnosis
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Paget’s Disease: Complications ... bone formation MSK ... PagetsDisease #pathophysiology ... #diagnosis #signs ... #symptoms #complications