The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology signs symptoms sle allergy immunology systemic anaphylaxis arteritis classification criteria definitions disease gastrointestinal giantcell hypersensitivity hypersensitivityreaction kawasaki manifestations msk
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Immunological Target: Allergen ... Ex: Antibiotic allergies ... • Ex: Systemic Lupus ... Erythematosus, ... Classification #Diagnosis
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... the pancreas, Vasculitis ... #Erythematosus ... Gastrointestinal #Complications ... signs #symptoms #diagnosis
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... #Systemic #Lupus ... #Erythematosus ... Musculoskeletal #Complications ... signs #symptoms #diagnosis
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
: • Systemic Lupus ... • Erythematosus ... HypersensitivityReaction #Allergy
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Subacute cutaneous lupus ... Livedo Reticularis, Vasculitis ... pathophysiology #diagnosis ... signs #symptoms #complications
Giant Cell (Temporal) Arteritis: Clinical findings and Complications Signs/Symptoms: - Headache (usually constant, superimposed by waves
Clinical findings and Complications ... Temporal #Arteritis #Complications ... Signs #Symptoms #diagnosis ... #Vasculitis
Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal
exposure to a likely allergen ... exposure to known allergen ... Signs / Symptoms / Complications ... pathophysiology #immunology #diagnosis
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
RA) or systemic lupus ... erythematosus ( ... Pathophysiology #Diagnosis
Kawasaki Disease: Clinical Findings Diagnostic Criteria - Fever and 4/5 of the following: • Conjunctivitis • Polymorphous
Clinical Findings Diagnostic ... Signs/Symptoms/Complications ... Disease #Criteria #Diagnosis ... Signs #Symptoms #Vasculitis
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