Algorithms in Medicine @MatthewHoMD
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Matthew Ho, MD PhD https://twitter.com/MatthewHoMD
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Iron Deficiency Anemia - Differential Diagnosis Algorithm

Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR

 • Blood loss:
Iron Deficiency ... Labs: Ferritin, iron ... • Blood loss: GI ... Hemodialysis • Iron ... Lactation, Low iron
Upper GI Bleed - Management Algorithm

Upper GI bleed Suspected: Melena, hematemesis, coffee-ground emesis, BRBPR
Initial Stabilization
Concern for
Upper GI Bleed - ... Algorithm Upper GI ... Disease Consult GI ... Causes of Upper GI ... MatthewHoMD #Upper #GI
Lower GI Bleed - Differential Diagnosis Algorithm

 • Structural: Diverticulosis, Hemorrhoids, Post-polypectomy, Polyps & malignancy, Anal
Lower GI Bleed - ... MatthewHoMD #Lower #GI
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
LDH, ESR, CRP, iron
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
inflammation) • Iron
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Non-renal losses: • GI
Suspected Celiac Disease - Diagnosis Algorithm

Celiac disease suspected:
 • Signs and symptoms of celiac disease
 •
celiac disease • Iron-deficiency
Lower GI Bleed - Management Algorithm

Suspected lower GI bleeding (LGIB):
 • Hematochezia 
 • Melena +
Lower GI Bleed - ... Suspected lower GI ... Rule out upper GI ... MatthewHoMD #Lower #GI
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
Hypovolemic (H2O loss): GI
Additional Modalities for Workup of GI Bleed (Other than EGD + Colonoscopy)

Pill endoscopy
 • Able to
for Workup of GI ... MatthewHoMD #GI