15 results
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
, Chronic disease ... Liver Disease, MDS ... myeloma Rouleaux: Chronic ... differential #diagnosis #hematology ... #microscopy #atlas
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Signs of anemia ... • Extrinsic RBC ... • Intrinsic RBC ... Matthew Ho, MD ... #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
Algorithmic Approach ... Spherocytosis, G6PD, PK, HbC ... Reticulocytosis, MDS ... #MCV #Algorithm ... Differential #Diagnosis #hematology
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Illness Script Signs ... Treatment: • Consider ... Can progress to MDS ... diagnosis #management #treatment ... #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Artifact (redo CBC ... : • Acute or Chronic ... effect following treatment ... Iron deficiency anemia ... #Causes #Hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
myelodysplastic syndrome (MDS ... Hypocellular/Hypoplastic MDS ... abnormalities typical for MDS ... Pancytopenia: • ↓ RBC ... Treatment:
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
hemolysis, deficiency anemia ... Rebound effect from treatment ... Inflammatory Conditions: Rheumatologic ... • Infections: Chronic ... Matthew Ho, MD
Polycythemia Vera (PV) - Diagnosis and Management Summary
Diagnostic Criteria:
 • Elevated hemoglobin and/or hematocrit AND
 •
incidentally via CBC ... present, symptoms, signs ... transformation into AML or MDS ... • Treatment algorithms ... #hematology
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
Differential Diagnosis Algorithm ... T-cell - CD7, CD3 Chronic ... Pelger-Huet, Macrocytic anemia ... bcr-able (+) ↑ WBC ... - Amy Chung, MD
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Chronic Lymphocytic ... Vmphocytosis on routine CBC ... 5) Symptoms of anemia ... marrow failure with anemia ... Lauren Banaszak, MD