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differential causes management thrombocytosis classification oncology rheumatology acidosis aclf approach blood cancer cirrhosis ckd disorders elevation erythematosus extravascular failure gastroenterology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Algorithm Spurious ... Infectious: • Acute ... effect following treatment ... malignancy • Iron deficiency ... anemia #Thrombocytosis
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Algorithm Acute ... - CD7, CD3 Chronic ... Pelger-Huet, Macrocytic anemia ... • Lymphoid (CLL ... Blood #Disorders #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Index > 3: • Acute ... defects (e.g. sickle cell ... anemia, G6PD deficiency ... Production #Index #hematology ... #diagnosis #calculation
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... Algorithm Blood ... Loss • Acute ... • Anemia of Chronic ... #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Algorithm Decreased ... RA, SLE, PRV, Chronic ... Normal RBCs • Acute ... • Early Iron Deficiency ... #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... , deficiency anemia ... Rebound effect from treatment ... • Infections: Chronic ... #Algorithm #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential Diagnosis ... • Sickle cell ... immune-complex hemolytic anemia ... • Acute HTR ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis): • Acute ... malignancies • Anemia ... specifically: iron deficiency ... myeloid leukemia (CML ... #Causes #hematology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... in those with CLD ... months without treatment ... Lung Failure Circulation ... gastroenterology #management #diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... • Neutropenia, anemia ... microglobulin Treatment ... ’s lymphoma or acute ... workup #oncology #hematology
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