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diagnosis management differential lupus autoantibodies dermatology erythematosus systemic antibodies clinical comparison idiopathic monoclonal myositis oncology signs sle symptoms activation acute
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Associations ANA ... La) - Sjogren's syndrome ... Goodpasture's syndrome ... Autoantibodies #Associations ... #table #rheumatology
Connective tissue disease-associated interstitial lung diseases LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
interstitial lung diseases ... PSS: Sjogren syndrome ... Differential #Comparison #Table ... #Pulmonary #Rheumatology ... #Associations
Idiopathic Inflammatory Myopathies (IIM's) RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's) • Overlap Myositis
that occurs in association ... connective tissue disease ... antisynthetase syndrome ... IIMs #diagnosis #rheumatology ... #dermatology #Myopathy
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
Anti-Synthetase Syndrome ... Mediated Necrotizing Myopathy ... clinical #diagnosis #rheumatology ... #table
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... LAC) • Sjogren Syndrome ... Autoantibodies #Rheumatology ... #diagnosis #associations ... #table
Diagnostic Criteria for Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis) Major criteria 1. Abrupt onset of tender
for Sweet Syndrome ... Association with ... inflammatory disease ... neutrophils #Sweet #Syndrome ... #Diagnosis #Hematology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
thromboembolic disease ... vasculitis • Hematologic ... (MDS) Most met criteria ... for 1) hematologic ... Autoinflammatory #Somatic #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
with disease activity ... SLE-SSc-AlM overlap syndromes ... with auto-immune diseases ... erythematosus #diagnosis #rheumatology ... #table #ANA
Behcet's Syndrome - Diagnosis Diagnostic Criteria for Behget's Syndrome (International Study Group for Behget's Disease): • Recurrent,
Behcet's Syndrome ... Diagnosis Diagnostic Criteria ... for Behget's Syndrome ... the following 4 criteria ... #criteria #rheumatology
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
the population Disease ... Causes and clinical associations ... Autoimmune diseases ... Urticaria #diagnosis #rheumatology ... #comparison #table
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