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Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Immune-Mediated • Warm AIHA ... • Cold AIHA ... • Drug-induced AIHA ... Diagnosis #Algorithm #Causes
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Extravascular Causes ... - Autoimmune (AIHA ... - Autoimmune (AIHA ... Extravascular #Causes
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Antibody Autoimmune Hemolytic ... 1) DIAGNOSE AIHA ... reticulocytes • Hemolysis ... 2) LOOK FOR a cause ... screening 3) TREAT AIHA
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Diagnosis for Hemolytic ... Anemia Intrinsic Causes ... Hypersplenism • AIHA ... Intravascular Causes ... udaygulati #Hemolytic
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... Table Warm AIHA ... #Autoimmune #Hemolytic ... #Anemia #AIHA #
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... of anemia and hemolysis ... Immune-mediated Hemolysis ... • Autoimmune Hemolytic ... Anemias (AIHAs)
Autoimmune Hemolytic Anemia (AIHA) WARM AHA - Primary - Idiopathics - Secondary Infectious • Viral- HIV, EBV, HCV, HEV •
Autoimmune Hemolytic ... Anemia (AIHA) ... WARM AHA - Primary ... #Autoimmune #Hemolytic ... #Anemia #AIHA #
Autoimmune Hemolytic Anemia (AIHA) Treatment Warm AIHA: 1) Steroids - 1-2 mg/kg prednisone daily • Until
Autoimmune Hemolytic ... Anemia (AIHA) Treatment ... Warm AIHA: 1) Steroids ... > 10, no more hemolysis ... #Autoimmune #Hemolytic
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Autoimmune Hemolytic ... - Warm vs Cold AIHA ... Warm AIHA: - 70% ... spherocytes Cold AIHA ... #Autoimmune #Hemolytic
Hemolysis Classification - Intrinsic and Extrinsic Causes Commentary: Another way to think of immune hemolysis would be
Hemolysis Classification ... and Extrinsic Causes ... think of immune hemolysis ... autoimmune (most of the causes ... Differential #Diagnosis #Causes
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