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diagnosis clinical management differential cardiology algorithm pocus neurology video physicalexam radiology treatment pharmacology criticalcare pulmonary ultrasound causes ebm hepatology echocardiogram
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Injury • AST/ALT ... elevation > Alk ... phos • ALT more ... • R value = (ALT ... + ULN ALT) / (alkaline
Alectinib versus Crizotinib in Untreated ALK-Positive Non–Small-Cell Lung Cancer #EBM #Honc #Alectinib #Crizotinib #ALK #ALKPositive #NSCLC
Crizotinib in Untreated ALK-Positive ... Alectinib #Crizotinib #ALK
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
R-value: Serum (ALT ... /ULN ALT) / (Alk ... phos/ULN ALP) ... Liver Failure (ALF ... • AST/ALT > ALP
HAS-BLED Score - Risk of Major Bleeding in 1 Year Characteristics (1 point each) • Hypertension: Baseline
2x ULN, or AST/ALT ... /Alk phos > 3x ULN
Hypophosphatemia - Differential Diagnosis Algorithm Appropriately Low Kidney Phosphate Excretion: • Decreased GI Absorption: Chronic Diarrhea, Antacids,
Hyperparathyroidism, TKI, ALK
Anaplastic large cell lymphoma, ALK+ Clinical • First 3 decades of life, M>F • Often nodal +
cell lymphoma, ALK
T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia Clinical - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
Negative for EBER, ALK
Dilated Distal Common Bile Duct on POCUS Male with RUQ abdominal pain for 2 days. GB
elevated WBC, AST/ALT ... , Alk Phos, T Bili
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 Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
kidney, brain ALT ... for the liver ALP ... Transaminase, ALP ... / ULN ALT) / (ALP ... / ULN ALP)
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
or AST > ALP): ... • Severe - ALT ... • Moderate - ALT ... Others • Mild - ALT ... > ALT or AST):
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