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Antiphospholipid Syndrome (Hughes' Syndrome) Antiphospholipid syndrome - an autoimmune condition where the affected individual produces antibodies
Antiphospholipid Syndrome ... (Hughes' Syndrome ... Antiphospholipid syndrome ... #Hughes #Syndrome ... #APLS #Signs #Symptoms
Antiphospholipid Syndrome (APS) APS is a rare autoimmune disorder characterized by recurring blood clots resulting from antibodies
Antiphospholipid Syndrome ... (APS) APS is a ... Antiphospholipid antibodies (aPL ... 1 of the three aPLs ... Antiphospholipid #Syndrome
Recurrent / Breakthrough DVT During Anticoagulation Subtherapeutic Anticoagulation Hypercoagulable State - Antithrombin deficiency - Hypercoagulability ot
Behcet's disease - APLS ... - May-Thurner syndrome
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
hemolytic-uremic syndrome ... anemia" • HELLP syndrome ... • Catastrophic APLS
Raynaud Phenomenon Differential Diagnosis: Rheumatologic - MCC systemic sclerosis, RA, SLE, Sjogren syndrome, Antisynthetase syndrome, MCTD Heme -
, SLE, Sjogren syndrome ... Antisynthetase syndrome ... Hypercoagulable state (eg APLA ... Carpal tunnel syndrome ... Reynaud #Phenomenon #Syndrome
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Pulmonary Renal Syndromes ... Antiphospholipid Syndrome ... differentiation syndrome ... in APL - Cardiac ... Pulmonary #Renal #Syndromes
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Incidence: common in APL ... unless severe APLS ... Differentiation #Syndrome
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
SLE • CLL • APLA ... Non-lmmune: • HELLP Syndrome
Low-dose aspirin and low-molecular-weight heparin in lupus and Antiphospholipid Syndrome (APS) pregnancy • No previous history of
Antiphospholipid Syndrome ... (APS) pregnancy ... BUT high-risk aPL ... Antiphospholipid #Syndrome ... #APS #pregnancy
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Hyperviscosity, TTP, APLS ... • Nephrotic Syndrome ... Antiphospholipid antibodies (APLS
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