16 results
Primary and Secondary Causes of Mitral Regurgitation
Primary (organic) chronic mitral regurgitation:
 • Leaflet: Rheumatic fever, Infective
inflammation (SLE ... • Prosthetic valve ... annulus valve: ... Regurgitation #differential ... #diagnosis #cardiology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Fever (50%), Depression ... Pericarditis, Endocarditis ... , Aortic valve lesions ... Abdominal pain ... #rheumatology
Top 10 situations when to think about lupus
1) Inflammatory joint pain (especially in the wrists and
the face (many differential ... 9) Unexplained fever ... #diagnosis #sle ... #clues #system ... erythematosus #rheumatology
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Subacute bacterial endocarditis ... Cardiovascular system • Mitral ... conditions #joint #pain ... #differential # ... diagnosis #rheumatology
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
• Rheumatic fever ... lesions • Discoid lupus ... dermatology #joint #pain ... #skin #rashes #differential ... #diagnosis #rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
quinine, etc) - Viral ... - Autoimmune: SLE ... - Mechanical: valve ... replacement, endocarditis ... #hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... permanent alopecia Differential ... Arthritis: • Joint pain ... • Libman-Sacks endocarditis ... Cytopenias • Cardiac valve
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Involves aortic and mitral ... • Autoimmune (SLE ... night sweats, fever ... Marantic (NTBE) Differential ... #Endocarditis #diagnosis
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
proximal joints, Fever ... Detectable HIV viral ... Myopathies #myopathy #differential ... #diagnosis #comparison ... #rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
- Arthritis Differential ... Diagnosis Framework ... • Bacterial endocarditis ... #Differential # ... Diagnosis #MSK #