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Guide to Acute Kidney Injury (AKI)

What to ask/look for: 
 - HPI, PMH, full ROS
Kidney Injury (AKI ... Causes of Inpatient AKI ... Liano 1996) - ATN ... disease — 21% - AKI ... CKD— 13% (mostly ATN
Acute Kidney Injury (AKI) - Common Patterns on Urinalysis
 - Prerenal
 - ATN
 - AIN
 -
Kidney Injury (AKI ... - Prerenal - ATN ... EricsMedicalLectures/ #AKI
Causes of Acute Kidney Injury - Differential Diagnosis Framework 
Pre-Renal
Post-Renal
Intrinsic Renal:
 • Tubules (ATN)
 • Glomerular:
: • Tubules (ATN ... drtonydang @CMC_IM #AKI
Acute Kidney Injury (AKI) - Differential Diagnosis Framework
Pre-Renal:
 • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Kidney Injury (AKI ... C3/C4, Other • ATN ... Medicine @SCVMCMed #AKI
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
Kidney Injury (AKI ... Cisplatin • ATN ... bevacizumab (VEGFi), TKi ... Kidney #Injury #AKI
Medications causing Acute Kidney Injury (AKI)
Prerenal:
 • Dehydration: Diuretics
 • Altered intrarenal autoregulation: ACEIs / ARBs,
Kidney Injury (AKI ... Intrarenal: • ATN ... EricsMedicalLectures/ #AKI
Acute Kidney Injury (AKI) - Differential Diagnosis Framework
Prerenal:
 • Due to true volume loss or decreased
Kidney Injury (AKI ... interstitium • ATN ... Kidney #Injury #AKI
Common causes of Acute Kidney Injury AKI - Differential Diagnosis
HEMODYNAMIC
 • Cardiac failure: Impaired forward flow,
Kidney Injury AKI ... Injury/Necrosis (ATN ... Koratala @NephroP #AKI
Simplified Approach to Acute Kidney Injury (AKI)
1) IS THIS AN EMERGENCY? 
Is there a dialysis indication
Kidney Injury (AKI ... PROBLEM ~80% of AKI ... etiologies due to ATN ... LorinskyMD #AKI
Acute Kidney Injury (AKI) - Management Principles
Prerenal - Correct hemodynamic derangements:
 • If low preload →
Kidney Injury (AKI ... underlying disease • ATN ... EricsMedicalLectures/ #AKI