5275 results
Iron Deficiency in Heart Failure
Pathophysiology:
Chronic heart failure leads to an increase in inflammatory cytokines → Inflammation
→ Inflammation causes ... decreased iron absorption ... endpoint of all-cause ... heartfailure #diagnosis #management
Hypermagnesemia - Diagnosis and Management

Hypermagnesemia is a serum magnesium concentration > 2.6 mg/dL.
Symptoms include hyporeflexia, hypotension,
Diagnosis and Management ... mortality in ICU Causes ... renal magnesium absorption ... helpful in severe cases ... Hypermagnesemia #Diagnosis #Management
Hypercalcemia of Malignancy - Pathophysiology
PTH-mediated
 • Parathyroid cancer
 • Ectopic production: Small cell lung cancer, ovarian
intestinal calcium absorption ... and stimulates resorption ... Stimulate calcium reabsorption ... kidney, Stimulates resorption
Parathyroid Hormone (PTH) Effect in Calcium and Phosphorus
Calcium - Net Effect Hypercalcemia:
   ↑ intestinal
↑ intestinal absorption ... ↑ bone reabsorption ... ↑ tubular reabsorption ... Hypophosphatemia: ↑ bone reabsorption ... ↓↓ tubular reabsorption
Hypercalcemia - Hormones and Pathophysiology  
Calcitriol:
 • Bones: Enhances mineralization
 • GI Tract: ↑ Ca2+
Tract: ↑ Ca2+ absorption ... , ↑ PO4- absorption ... , ↑ PO4- reabsorption ... Tract: ↓ Ca2+ absorption ... , PO4- reabsorption
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... PA - impaired absorption ... Deficiency #diagnosis #management
Causes of Hypercalcemia
Hypercalcemia due to increased bone Ca2+ resorption:
 • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
Causes of Hypercalcemia ... increased bone Ca2+ resorption ... increased GI Ca2+ absorption ... Hypercalcemia #Causes
Hypercalcemia - Differential Diagnosis Algorithm
Elevated PTH (High or normal):
 • Primary Hyperparathyroidism
 • Familial Hypocalciuric Hypercalcemia
Low
Miscellaneous - Bone Resorption ... - Calcium Reabsorption ... Diagnosis #Algorithm #causes
Oral Hypoglycemics in Diabetes Management
1  INSULIN SENSITIZER
 • TZD 
     -
Hypoglycemics in Diabetes Management ... Diabeta) 3 CARB ABSORPTION ... slows gut starch absorption ... tubule glucose reabsorption ... Hypoglycemics #Diabetes #Management
The Pathophysiology of Fat Absorption and Causes of Malabsorption (steatorrhoea)

#Fat #Malabsorption #Pathophysiology #Differential #Steatorrhea #Diarrhea #Diagnosis
Pathophysiology of Fat Absorption ... and Causes of Malabsorption