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Characteristics of Commonly Used Phosphate Binders Aluminum - Potent and effective - Useful for
- No systemic absorption ... - Significant absorption ... of iron that may ... decrease iron and ... Phosphate #Binders #Table
Phosphate Binders - Pros and Cons Calcium carbonate (TumsTM) - Most inexpensive, antacid properties useful for
less GI calcium absorption ... Trivalent iron containing ... Phosphate #Binders #Table
Iron - Possible Routes of Administration and Fate in the Organism #Iron #Absorption #Routes #Pathophysiology #pharmacology #Oral
Iron - Possible ... the Organism #Iron ... #Absorption #Routes
Hypercalcemia of Malignancy - Pathophysiology PTH-mediated • Parathyroid cancer • Ectopic production: Small cell lung cancer, ovarian
intestinal calcium absorption ... and stimulates resorption ... Stimulate calcium reabsorption ... kidney, Stimulates resorption
Parathyroid Hormone (PTH) Effect in Calcium and Phosphorus Calcium - Net Effect Hypercalcemia: ↑ intestinal
↑ intestinal absorption ... ↑ bone reabsorption ... ↑ tubular reabsorption ... Hypophosphatemia: ↑ bone reabsorption ... ↓↓ tubular reabsorption
Hypercalcemia - Hormones and Pathophysiology Calcitriol: • Bones: Enhances mineralization • GI Tract: ↑ Ca2+
Tract: ↑ Ca2+ absorption ... , ↑ PO4- absorption ... , ↑ PO4- reabsorption ... Tract: ↓ Ca2+ absorption ... , PO4- reabsorption
Causes of Iron Deficiency • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
Causes of Iron Deficiency ... Vitamin C • ↓ Absorption ... Others: Hemolysis, Iron ... @drkeithsiau #Iron
Iron Deficiency in Heart Failure Pathophysiology: Chronic heart failure leads to an increase in inflammatory cytokines → Inflammation
Iron Deficiency ... leads to decreased iron ... absorption and ... iron release Diagnosis ... Treatment - IV Iron
Iron Deficiency Anemia vs Anemia of Chronic Disease - Laboratory Testing SUMMARY: - RDW, FEP, serum iron,
Iron Deficiency ... RDW, FEP, serum iron ... TIBC-specific for iron ... - Bone marrow iron ... Testing #Comparison #Table
Causes of Iron Deficiency - Differential Diagnosis Algorithm • Blood loss: GI (cancer, ulcer, IBD), GU
Causes of Iron Deficiency ... Hemodialysis • Iron ... Lactation, Low iron ... Decreased ferrous iron ... loss of sites of absorption
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