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Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
Erythematosus ... Lupusreference #Renal #diseases ... #SLE #Systemic ... #Lupus #Erythematosus ... #venn #nephrology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... 40, F:M 9:1 • Clinical ... Photosensitivity, Alopecia ... Evolution: Chronic disease ... #Erythematosus
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Suspect: Clinical ... and permanent alopecia ... lymphoproliferative syndrome Clinical ... • Nonscarring alopecia
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... Erythematosus Clinical ... - NON-SCARRING ALOPECIA ... SEROSITIS - RENAL - NEUROLOGIC ... #Lupus #Erythematosus
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
Erythematosus ... Clinical Domains ... : Non-scarring alopecia ... least 2 joints • Neurologic ... Classification #Criteria #SLE
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
likely it will be clinically ... erythematosus ( ... erythematosus ( ... erythematosus ( ... : Lupus (SLE), Systemic
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus ( ... SLE) Clinical ... Cerebrovascular Disease ... #Erythematosus ... #SLE #CNS #neurology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Erythematosus ( ... 40, F:M 9:1 • Clinical ... Photosensitivity, Alopecia ... Evolution: Chronic disease
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Association with disease ... Farr assay) and lupus ... is clinically suspected ... with auto-immune diseases ... #erythematosus
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features ... of Systemic Lupus ... (SLE) General: ... pain (20%) Renal disease ... #erythematosus #