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differential hematology algorithm hemolytic management oncology disorders extravascular intravascular mcv neutropenia thrombocytopenia thrombocytosis allergic allergy aplastic calculation chronic clinical common
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic ... Algorithm and Causes ... #Hemolytic #Anemia ... #Workup #Hematology ... #Diagnosis *
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... anemia): ... ) - Drugs ( ... #hematology #anemia
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... • Bleeding • Hemolysis ... Inflammation, Chronic Infection ... Deficiency • Drugs ... #MCV #Classification
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... - Differential Diagnosis ... circulation - Infections ... anemia • ... #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... - Differential Diagnosis ... autoimmune disease, drugs ... Fevers, DAT (-) → Infection ... #causes
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
for Hemolytic Anemia ... AIHA: warm, cold, drug ... induced • Infections ... #Diagnosis #causes ... #classification
Causes of Hemolytic Anemia - Differential Diagnosis Inherited • Membrane • Internal - Hemoglobin
Causes of Hemolytic ... Anemia - Differential ... Internal - Infectious ... #Diagnosis #Causes ... #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential Diagnosis ... , CKD • Hemolytic ... Macroangiopathic, Infections ... Orotic aciduria, Drugs ... #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
(e.g. cancer, infection ... suppression (e.g. drugs ... Microangiopathic hemolytic ... G6PD deficiency), Infections ... #diagnosis #calculation
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Internal (RBC) - Infections ... Defects: Sickle cell anemia ... #hematology
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