33 results
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Chronic - ongoing ↑ LFTs ... #gastroenterology ... #algorithm #gastroenterology ... #hepatology
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Liver Enzymes (LFTs ... Cholestatic Liver Injury ... Hepatocellular Liver Injury ... Liver #Enzymes #LFTs ... #differential #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Function Tests (LFTs ... Drug-induced liver injury ... Function #Tests #LFTs ... Differential #Diagnosis #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Function Test (LFTs ... Hepatocellular injury ... 2: Cholestatic injury ... #FunctionTest #LFTs ... Transaminitis #diagnosis #hepatology
Management and Complications of Cirrhosis and Ascites

Ascites Workup Algorithm
Ascites Management
Refractory Ascites
Hyponatremia
Spontaneous Bacterial Peritonitis (SBP)
Hepatic Hydrothorax
AKI in
Management and Complications ... Algorithm Ascites Management ... Complications #diagnosis #management ... #gastroenterology ... #hepatology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver Injury ... Patterns #Liver #Injury ... #hepatology #LFTs
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Drug-Induced Liver Injury ... Hepatitis Procedures Management ... Failure #Cirrhosis #Hepatology ... #gastroenterology ... #management #diagnosis
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver Injury ... Framework: Liver Injury ... Hepatocellular Liver Injury ... Differential #Diagnosis #hepatology ... Transaminitis #LFTs
Disorders of the Hepatic and Mesenteric Circulation

Platelets in Cirrhosis
Hypercoagulability in Cirrhosis
Bleeding in Cirrhosis
Portal Vein Thrombosis (PVT)
Mesenteric
Circulation #Disorders #Hepatology ... #Gastroenterology ... #diagnosis #Management
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Function Tests (LFTs ... hepatocellular injury ... Function #Tests #LFTs ... Interpretation #diagnosis #hepatology