23 results
Tumor lysis syndrome (TLS) - Pathophysiology:
→ Massive tumor cell lysis
→ Release of large amounts of K+,
Tumor lysis syndrome ... (TLS) - Pathophysiology ... therapy of ALL, AML ... uric acid and /or calcium ... #TLS #Pathophysiology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... in APML Epidemiology ... Triggers: ATRA treatment ... Pathophysiology ... initiation • Differential
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... organ damage • Treatment ... : • Pathophysiology ... • Treatment: ... - Hyperkalemia treatment
Causes of Hypercalcemia
Hypercalcemia due to increased bone Ca2+ resorption:
 • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
histoplasmosis) • Milk (calcium ... )-alkali syndrome ... Hypercalcemia #Causes #differential ... #diagnosis #calcium ... #high #endocrinology
Hypocalcemia - Diagnosis and Management
PTH Independent (↑ PTH)
 • LOW VIT D
    -
Formation: Hungy Bone Syndrome ... - Calcium Sequestration ... - DiGeorge Syndrome ... Diagnosis #Management #endocrinology ... #differential #
Hyperviscosity Syndrome - Causes and Treatment

 - Waldenstrom macroglobulinemia (most common) / Plasmapheresis 
 - Multiple
Hyperviscosity Syndrome ... - Causes and Treatment ... hyperleukocytosis (AML ... #Causes #Differential ... #Diagnosis #Treatment
Hypocalcemia - Differential Diagnosis Algorithm - Low and High Phosphate
LOW PHOSPHATE
 - Low/NormaI PTH
Hypocalcemia - Differential ... Phenytoin, Nephrotic Syndrome ... Activating Mutation in Calcium ... #Hypocalcemia #Differential ... Algorithm #Phosphate #endocrinology
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
Rhabdomyolysis - Differential ... iniury, Compartment syndrome ... Neuroleptic malignant syndrome ... Dermatomyositis) AKI - Pathophysiology ... potassium and calcium
Short Stature - Differential Diagnosis Algorithm
Normal Variant, Normal Puberty Onset (BA = CA)
 • Familial Short
Short Stature - Differential ... • Turner Syndrome ... Panhypopituitarism Treatment ... #ShortStature #Differential ... Diagnosis #Algorithm #endocrinology
Causes of Hypercalcemia
Parathyroid gland structure-related
 • Primary hyperparathyroidism
 • Parathyroid adenoma
 • Parathyroid hyperplasia
 • Parathyroid
Lithium use • Calcium-sensing ... • Milk-alkali syndrome ... Hypercalcemia #Causes #endocrinology ... #diagnosis #differential