23 results
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
Associated Features: Diagnosis ... over years, often diagnosed ... #differential #diagnosis ... #comparison #rheumatology ... #table
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
NXP2, Mi-2, SAE Anti-Synthetase ... Antibodies #MSAs #clinical ... #diagnosis #rheumatology ... #table
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... 40, F:M 9:1 • Clinical ... druginduced #lupus #sle #comparison ... #table #rheumatology ... #diagnosis #management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE) - Diagnosis ... 40, F:M 9:1 • Clinical ... Positive in 60-80% of cases ... Erythematosus #Diagnosis ... Management #Summary #rheumatology
Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group

< 5%
cryoglobulinemia vasculitis - Diagnosis ... , causes and management ... cryoglobulinemia vasculitis Clinical ... - Specific anti-infectious ... Cryoglobulinemia #Vasculitis #Rheumatology
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
child * Severe cases ... Obstetrics #OBGyn #Hematology ... #Diagnosis #Comparison ... #Table
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Anti-histone 60 ... -15% If SLE is clinically ... erythematosus #diagnosis ... #rheumatology # ... table #ANA
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
child * Severe cases ... AFLP #obstetrics #hematology ... #diagnosis #table ... #comparison
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
auricular papules Clinical ... Women • ~20% of cases ... Men • ~50% of cases ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
decades of life Causes ... and clinical associations ... Cold #Urticaria #diagnosis ... #rheumatology # ... comparison #table