5889 results
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Erythematosus - Diagnosis ... 5-10% - Anti- ... 5-15% - Anti-Ku ... Differential Diagnosis ... Erythematosus #Diagnosis
Main types of autoimmune encephalitis in the ICU. 
Anti-NMDAR anti-N-methyl-d-aspartate receptor, ADEM acute disseminated encephalomyelitis, Anti-GFAP
Anti-NMDAR anti-N-methyl-d-aspartate ... anti-glial fibrillary ... anti-gamma aminobutyric ... anti-leucine-rich ... table #neurology #diagnosis
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
- SLE Anti-histone ... (AMA), Anti-sp100 ... - SLE Anti-SSA ... (Ro), Anti-SSB ( ... Associations #diseases #diagnosis
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
, anti-Mi-2, anti-TIF ... -1, anti-NXP-2 ... Associated Features: Diagnosis ... over years, often diagnosed ... #differential #diagnosis
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Lupus (SLE): ANA (anti-nuclear ... , Anti-Ro (SSA) ... and Anti-La (SSB ... (SSA), Anti-La ... #Rheumatology #diagnosis
Systemic Sclerosis Associated Autoantibodies
Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis
Anti-centromere: Limited skin disease (~93-95%), Pulmonary
Autoantibodies Anti-topoisomerase ... I (anti-Sc170): ... Biliary Cirrhosis Anti-RNA ... skin fibrosis Anti-PM-Sc1 ... Autoantibodies #diagnosis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
Anti-dsDNA (in 70% ... Anti-Sm (Smith) ... Anti-histone (in ... Anti-Ro/SSA ... Antineutrophil #antibodies #diagnosis
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
SHARP - Lupus Diagnosis ... Immunoglobulins (Anti-dsDNA ... , Anti-Sm, Anti-phospholipid ... #rheumatology #diagnosis
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
Elevated CK, +Anti-Jo ... , +Anti-Mi2 Dermatomyositis ... Elevated CK, +Anti-Jo ... , +Anti-Mi2 Polymyalgia ... #differential #diagnosis
You’ll notice there is an IgM and an IgG core antibody. The presence of IgM anti-HBc
presence of IgM anti-HBc ... IgM anti-HBc is ... presence of IgG anti-HBc ... with HBV, IgG anti-HBc ... #Diagnosis #HepB