627 results
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Goodpasture's Disease ... • Labs: CBC, cr ... testing: anti-ANCA ... ab, anti-GBM ab ... • CXR (diffuse
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Autoantibodies and their Disease ... - Graves' disease ... connective tissue disease ... (TTG) - Celiac disease ... #Associations #diseases
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
Anti-dsDNA (in 70% ... Anti-histone (in ... connective tissue disease ... disease - MPO>PR3 ... #rheumatology #diseases
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
60-70% - Anti-SSA ... 5-10% - Anti- ... 5-15% - Anti-Ku ... auto-immune, Infectious diseases ... sclerosis, Still's disease
Differentiating Pacemaker vs ICD on Chest XRay
 - Single Chamber PPM
 - Single Chamber ICD
 -
ICD #ChestXRay #CXR ... #Radiology #comparison ... #clinical #cardiology
Systemic Sclerosis Associated Autoantibodies
Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis
Anti-centromere: Limited skin disease (~93-95%), Pulmonary
Autoantibodies Anti-topoisomerase ... I (anti-Sc170): ... Diffuse skin disease ... : Limited skin disease ... Biliary Cirrhosis Anti-RNA
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
screening test Anti-dsDNA ... with more severe disease ... activity Anti-Ro ... Sjogren syndrome Anti-UI-ribonucleoprotein ... overlap syndrome) Anti-Smith
Radiographic Features of Pulmonary Diseases
 - Pneumonia
 - Atelectasis
 - Emphysema
 - Pneumothorax
 - Effusion
 -
Features of Pulmonary Diseases ... #Pulmonary #Diseases ... #Radiology #Patterns ... #Lung #CXR #XRay
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
of glomerular disease ... post-infectious GN Anti-Glomerular ... IF • Majority anti-neutrophil ... + • c-ANCA: anti-proteinase ... 3 (CPR) cytoplasmic
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Systemic lupus Anti-dsDNA ... Association with disease ... Anti-histone 60 ... neonatal lupus Anti ... with auto-immune diseases