6583 results
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
/full triad at diagnosis ... Around half of anti-SRP ... and anti-HMGCR ... after 2 years of treatment ... Autoimmune #Myositis #diagnosis
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE) - Diagnosis ... ANA > - Anti-ENA ... to 30% - Anti-dsDNA ... life-threatening • Treatment ... Erythematosus #Diagnosis
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
) - Anti-ENA ... ) - Anti-histone ... constitutional symptoms • Treatment ... life-threatening • Treatment ... #rheumatology #diagnosis
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
screening test Anti-dsDNA ... disease activity Anti-Ro ... overlap syndrome) Anti-Smith ... severe disease Treatment ... #SLE #Summary #diagnosis
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Hemolytic Anemia 1) DIAGNOSE ... bilirubin, ↑ LDH • Anti-RBC ... Hemolytic #Anemia #diagnosis ... #management #treatment
Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group

< 5%
cryoglobulinemia vasculitis - Diagnosis ... neuropathy Treatment ... - Specific anti-infectious ... the absence of anti-infectious ... Cryoglobulinemic #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... Unknown cause Treatment ... chemotherapy, anti-CD20 ... manifestations, Anti-IFN-y ... #management #treatment
Hantavirus
Pathogen: Hantavirus - Rodents are the primary reservoir
Transmission:
 • Shed in the urine, feces, saliva of
+/- diarrhea Diagnosis ... • Specific anti-hantavirus ... • Autopsy PCR Treatment ... #Hantavirus #diagnosis ... #management #treatment
Causes of Iron Deficiency
 • Inadequate Intake: Vegetarian/vegan diet, Malnutrition
 • Increased Body Needs: Infants/preschoolers, Pregnancy,
Pregnancy, EPO treatment ... surgery, PPIs, Anti-H2 ... #differential #diagnosis
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
Diagnosis - If suspected ... , AIH diagnosis ... ) (common, and Anti-LKM ... & Anti-ALC Abs ... regarding need for treatment