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diagnosis management clinical algorithm dermatology differential pharmacology rheumatology hepatology photo causes physicalexam video table skinrash syndrome ucsdh skin medications comparison
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
• Antibodies: Anti-Ro ... /SSA & Anti-La/SSB ... Antibodies: • Anti-Ro ... Nephrogenic DI Hematologic ... Adenocarcinoma Treatment
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
score ≥ 4, obtain Anti-PF4 ... Diagnosis #Management #Treatment ... #Hematology #HemeOnc
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
Immunoglobulins (Anti-dsDNA ... , Anti-Sm, Anti-phospholipid ... Pleuritis) H Hematologic ... erythematosus #rheumatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... , Anti-Ro (SSA) ... and Anti-La (SSB ... (SSA), Anti-La ... Autoantibodies #Rheumatology
Hypereosinophilia and Hypereosinophilic Syndrome • Secondary Hypereosinophilic Syndrome • Clinically Relevant HES Variants • When to
suspect underlying hematologic ... Diagnosis and Treatment ... Syndrome #HES #Hematology
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
papules 30% w/ anti-synthetase ... Around half of anti-SRP ... and anti-HMGCR ... after 2 years of treatment ... Myositis #diagnosis #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
screening test Anti-dsDNA ... disease activity Anti-Ro ... overlap syndrome) Anti-Smith ... severe disease Treatment ... Summary #diagnosis #rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
- SLE Anti-histone ... (AMA), Anti-sp100 ... - SLE Anti-SSA ... (Ro), Anti-SSB ( ... diagnosis #table #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
ANA > - Anti-ENA ... to 30% - Anti-dsDNA ... 60% - pANCA anti-MPO ... life-threatening • Treatment ... Management #Summary #rheumatology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Non malignant hematologic ... effect following treatment ... states • Non-hematologic ... Algorithm #Causes #Hematology
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