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Medications associated with drug-induced lupus

List of Definite and Possible Associated Drugs

#Diagnosis #Pharmacology #Medications #DrugInduced #Lupus #List
with drug-induced ... Possible Associated Drugs ... #Diagnosis #Pharmacology ... #Lupus #List #Causes ... #Differential #Drugs
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Causes of Extravascular ... delayed HTR • Drug-induced ... • PNH • Drug-induced ... anemia • ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... usually IgG) (e.g. lupus ... infection) - Drugs ... (Beta lactam antibiotics ... #hematology #anemia
Drugs Implicated in Hemolytic Anemia
 • Hapten (Drug binding to RBC membrane): Penicillin, Cephalosporin, Tetracycline, Tolbutamide,
Drugs Implicated ... in Hemolytic Anemia ... • Hapten (Drug ... #medications #Hemolytic ... #diagnosis #pharmacology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
for Hemolytic Anemia ... AIHA: warm, cold, drug ... induced • Infections ... #Diagnosis #causes ... classification #hematology
Drug-Induced Seizures - OTIS-CAMPBELL

O - Organophosphate, oral hypoglycemics, opioid
T - TCA, theophylline
I - Isoniazid, Insulin
S -
Drug-Induced Seizures ... Kat_Watson #Drug ... #Medication #Causes ... #Differential #Pharmacology ... #Diagnosis #OTISCAMPBELL
Drug Induced Systemic Lupus Erythematosus
> 100 drugs have been associated with drug-induced SLE
High risk (>5%):
 •
Drug Induced Systemic ... > 100 drugs have ... associated with drug-induced ... #drugs #pharmacology ... #differential #diagnosis
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Molecules • Ex: Antibiotic ... anemia, Penicillin-induced ... drug reaction, ... • Ex: Systemic Lupus ... Classification #Diagnosis
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
- Diagnosis Manifestations ... Lymphadenopathies 7% - Hemolytic ... anemia 4% - Myositis ... : Drug-induced lupus ... #differential #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... vs SLE Drug Induced ... cases, drug-dependent ... - Less common (drug-dependent ... drug +++, Hydroxychloroquine