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vasculitis differential management classification cryoglobulinemic hematology types bppv central comparison conditions cryoglobulins extrarticular hints involvement joint mixed monoclonal nephrology neurosarcoidosis
Renal involvement in 35% of mixed cryoglobulinemia vasculitis Associated with : • Absence of skin
• Absence of peripheral ... neuropathy • ... Combined decr of C3 and ... Vasculitis #Management #Rheumatology ... #Nephrology
Diagnosis of Cryoglobulinemia Vasculitis 1) Presence of cryoglobulin Circulating immunoglobulins that precipitate with cold temperature and dissolve
Diagnosis of Cryoglobulinemia ... purpura +++ • Peripheral ... neuropathy • ... #Vasculitis #Diagnosis ... #Rheumatology #
Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group < 5%
vasculitis - Diagnosis ... involvement - Less peripheral ... neuropathy ... #Vasculitis #Rheumatology ... #Diagnosis #Management
HINTS Exam - Distinguishing Central from Peripheral Vertigo • Head Impulse: Head thrust 10° with eyes
Distinguishing Central from Peripheral ... Vertigo • Head ... #Vertigo #diagnosis ... #neurology #bppv ... #comparison #table
Cryoglobulinemia Classification Types Type 1: Monoclonal IgM (rarely IgG/lgA) • Raynaud phenomenon, Digital ulcers/gangrene, Livedo reticularis, Hyperviscosity
Cryoglobulinemia ... kidney (MPGN), peripheral ... neuopathy, pulmonary ... Classification #Types #hematology ... #diagnosis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
neuropathy • ... skin necrosis, peripheral ... neuropathy, arthralgia ... Labs/Diagnosis: ... classification #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
et diutinum Neurologic ... Immunotactoid GN & Cryoglobulinemic ... WM: Vasculitis (Cryoglobulinemic ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... ANCA +MPO) • Cryoglobulinemic ... peripheral nerves ... Low levels mixed cryoglobulinemia ... #rheumatology #
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
• Peripheral nervous ... neuropathy, transverse ... peripheral Thyroid ... Vasculitis: • 7%, Cryoglobulinemia ... Sjogrens #Syndrome #Rheumatology
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
syndrome - SLE Neurologic ... neuropathy - SLE ... • Diminished peripheral ... #differential #diagnosis ... #rheumatology
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