97 results
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Deposition - Arthralgia ... , Arthritis - Migratory ... trabecular thinning -> Avascular ... Complications #pathophysiology ... #signs #symptoms
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
Acute Rheumatic Fever ... • Arthralgia ... Pancarditis and valvular ... RheumaticFever #pathophysiology ... #diagnosis #signs
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
Cell (Temporal) Arteritis ... yrs old; F>M Signs ... /Symptoms: - Fever ... #Pathophysiology ... #Diagnosis #Signs
Systemic Lupus Erythematosus (SLE) - Typical Signs/Symptoms
Alopecia, Fever, Malar rash, Photosensitivity, Adenopathies, Lupus pneumonia, Pleurisy, Pancreatitis,
SLE) - Typical Signs ... Symptoms Alopecia, Fever ... nephritis, Cytopenia, Arthralgia ... / arthritis, Myositis ... Erythematosus #SLE #Signs
Lyme Disease: Early and Late Clinical manifestations
Stage 1. Localized
 • EM appears 7-14 days at the
Fatigue, myalgia, arthralgia ... , headache, fever ... years after • Arthritis ... Disease #diagnosis #signs
Diagnosis of Cryoglobulinemia Vasculitis

1) Presence of cryoglobulin 
Circulating immunoglobulins that precipitate with cold temperature and dissolve
CRYOGLOBULINEMIA (type l) : Vascular ... and Ill) • Vascular ... neuropathy • Arthralgia ... , arthritis •
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad: Fever ... , Arthralgia/arthritis ... abnormalities • Muscular
Fever Patterns - Differential Diagnosis Framework

Continuous Fever:
Temp > 38°C with only 1 degree fluctuation in 24
Fever Patterns - ... Continuous Fever ... Juvenile idiopathic arthritis ... • Rheumatoid arthritis ... Brucellosis Faget's Sign
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
– symptoms and signs ... coarse skin, Arthralgia ... , Deafness Signs ... Myotonia, Muscular ... Hypothyroid #Features #Signs
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
- Fever spikes ... early evening • Arthritis ... , arthralgias • ... Arthralgias or arthritis ... A nonpruritic macular