15 results
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Causes of Extravascular ... - Differential ... MAHA (TTP, DIC, HUS ... Extravascular #Differential ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... uremic syndrome (HUS ... Extravascular #Causes ... #differential # ... diagnosis #hematology
Jaundice - Differential Diagnosis Algorithm
Pre-Hepatic - Unconjugated Hyperbilirubinemia
Increased Production
 • Hemolysis
 • Ineffective Erythropoiesis
 • Hematoma
Decreased
Jaundice - Differential ... Production • Hemolysis ... Hepatic Uptake • Sepsis ... Diagnosis #Algorithm #Causes ... #Hepatology #bilirubinemia
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... • MAHA: TTP, HUS ... #Anemia #Differential ... classification #hematology
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm

1. Definition: T.bili elevation + >20% conjugated
2. Obtain RUQ
Hyperbilirubinemia - Differential ... Obtain RUQ US to ... non-ICU vs ICU causes ... Diagnosis #Algorithm #gastroenterology ... #hepatology
Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... - Differential ... - Bacterial: Sepsis ... Microangiopathy: DIC, TTP, HUS ... Diagnosis #Framework #hematology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Liver Enzymes - Differential ... Drugs • TPN • Sepsis ... Others #LFTs #Hepatology ... #LiverEnzymes #Differential ... Diagnosis #Algorithm #Causes
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
Pregnancy - TTP/HUS ... defects. 1) HELLP (Hemolysis ... child * Severe cases ... AFLP #obstetrics #hematology ... #diagnosis #table
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... disease - DIC/TTP/HUS ... - Hemolytic ... : • DIC, TTP/HUS ... #Diagnosis #hematology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... TRALI): Leading cause ... Occurs between 0-6 hrs ... Can lead to sepsis ... diagnosis #management #hematology