13 results
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Thrombocytosis - Differential ... Infectious: • Acute ... disorders • Celiac disease ... effect following treatment ... Algorithm #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... → Refer to hematology ... Rebound effect from treatment ... Vasculitides, IBD, Celiac disease ... Diagnosis #Algorithm #hematology
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
Acute Kidney Injury ... LC deposition disease ... • Hematologic ... malignancies Treatment ... Cancer #Oncology #Differential
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Approach to Anemia - Differential ... Blood Loss • Acute ... Anemia of Chronic Disease ... Classification #Approach #Differential ... Algorithm #Causes #Hematology
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
Basophilia - Differential ... associated with the BCR-ABL1 ... translocation • Acute ... Colitis and Crohn’s Disease ... Diagnosis #causes #hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
Anemia of chronic kidney ... disease, Acute ... Alcohol use, Liver disease ... morphologic #mcv #differential ... diagnosis #causes #hematology
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
IgG4-Related Disease ... lesions, meninges, kidneys ... hypergammaglobulinemia, ↑ acute ... maintenance with GCs ... #rheumatology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
deficiencies: Chronic kidney ... disease, Hypothyroidism ... Index > 3: • Acute ... Production #Index #hematology ... #anemia #differential
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Definition: 
 • Severe adverse drug reaction, characterized by
Resolution > 15 days Differentials ... • SJS/TEN • Acute ... : symptomatic treatment ... • Severe disease ... DRESS #Syndrome #dermatology
Polycythemia - Differential Diagnosis Algorithm
Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Polycythemia - Differential ... Better call hematology ... oxygen sensing (at kidneys ... As with many disease ... Algorithm #workup #hematology