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Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
Acute Kidney Injury ... LC deposition disease ... Minimal change disease ... • Hematologic ... malignancies Treatment
Acute Kidney Injury - Classification
Prerenal:
 • Dehydration
 • Heart failure (a.k.a. cardiorenal syndrome)
 • Liver failure
Acute Kidney Injury ... a.k.a. cardiorenal syndrome ... a.k.a. hepatorenal syndrome ... necrosis (causes ... #diagnosis #nephrology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... Investigations: full blood ... osmolarity If cause ... #Kidney #Injury ... #causes
Hepatorenal Syndrome (HRS) - Diagnostic Criteria
HRS-AKI (Acute: previously known as HRS Type 1)
 • ↑ Creatinine
Hepatorenal Syndrome ... (Acute: previously ... structural kidney injury ... of kidney disease ... of kidney disease
Common causes of Acute Kidney Injury AKI - Differential Diagnosis
HEMODYNAMIC
 • Cardiac failure: Impaired forward flow,
Common causes of ... Acute Kidney Injury ... AKI - Differential ... inhibitors, hepatorenal syndrome ... #causes #Acute
Causes of Acute Kidney Injury ( AKI ) - Prerenal, Renal, and Postrenal

PRE-RENAL 
Impaired perfusion: 
•
Causes of Acute ... Kidney Injury ( ... AKI ) - Prerenal ... • Sepsis • Blood ... • Inflammatory disease
Causes of HyperKalemia - Differential Diagnosis
Increased extracellular K+:
 • Tissue injury
 • Hemolysis
 • Rhabdomyolysis
 •
K+: • Tissue injury ... • Tumor lysis syndrome ... glycosides • High acute ... dietary intake • Blood ... Elimination: • AKI
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Summary Causes ... UA positive for blood ... disease 2. ... #causes #treatment ... #nephrology
Acute Kidney Injury (AKI) - Management Principles
Prerenal - Correct hemodynamic derangements:
 • If low preload →
Acute Kidney Injury ... (AKI) - Management ... • Hepatorenal syndrome ... #Injury #treatment ... #management
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... have fever - ACS ... , AKI, acute limb ... TLS #diagnosis #management ... #hematology