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diagnosis differential management oncology blood pathophysiology polycythemia product reactions workup anemia apl apml arthritis auer centralretinalartery chronic classification clinical cll
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Differential Diagnosis Algorithm ... Chronic Myelogenous Leukemia ... Infectious: • Acute ... #Causes #Hematology
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
Acute promyelocytic ... leukemia (blood ... I see all of these ... features in most cases ... APML #Pathology #Hematology
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm Infection • Bacterial • Abscess • Viral Medications
Causes of Neutrophilia ... Differential Diagnosis Algorithm ... Polycythemia vera Acute ... Leukemia (pancytopenia ... #Causes #Hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Differential Diagnosis Algorithm ... Fatigue • Acute ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Differential Diagnosis Algorithm ... Leukemia, Tumour ... Autoimmune • ITP • SLE ... #Causes #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, APML, CLL Acute ... ALL (Acute Lymphoblastic ... -> AML: Blast crises ... Blasts APML (Acute ... #Hematology #Oncology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Differential Diagnosis Algorithm ... RA, SLE, PRV, Chronic ... Normal RBCs • Acute ... #Causes #Hematology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... B-Cell ~90% • Low ... Treated Like Acute ... Leukemias, very ... pathophysiology #Hematology
Causes of Polycythemia (Erythrocytosis) - Differential Diagnosis Algorithm Relative - Normal RBC Mass / Decreased Plasma Volume
Causes of Polycythemia ... Differential Diagnosis Algorithm ... • Burns • Diarrhea ... JAK-2 Positive - Low ... #Causes #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic Leukemia ... non-Hodgkin lymphoma SLL ... CBC • Confirm: Flow ... ’s lymphoma or acute ... workup #oncology #hematology
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