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diagnosis signs differential symptoms erythematosus lupus workup disease syndrome treatment autoimmune dermatomyositis myositis vasculitis activation algorithm anesthesia anesthesiology antinxp2 antinxp2dm
Cutaneous and Systemic Findings in Dermatomyositis Cutaneous Findings: - Heliotrope sign and edema - Nail-fold changes -
- Heliotrope sign ... or shawl sign ... - Gottron's sign ... - Interstitial lung ... Dermatomyositis #Diagnosis #Rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... - Summary Antinuclear ... #Summary #diagnosis ... #rheumatology # ... management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... and Management ... Summary • Epidemiology ... #lupus #Systemic ... #Summary #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Lupus (SLE) General ... effusion, Restrictive lung ... Thrombocytopenia #Lupus #SLE ... #signs #symptoms ... #diagnosis #rheumatology
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
weakness, less systemic ... heliotrope rash, Shaw sign ... , holster sign, ... Can also see mechanics ... Myositis #diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Myositis 4% - Lung ... #Systemic #Lupus ... autoantibodies #signs ... #differential #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Seen in: • Systemic ... rash) • Heart, lung ... erythematosus [SLE ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
female, asian • Systemic ... biliary, renal, lung ... increased IgG4+ cells ... Disease #diagnosis #management ... workup #treatment #rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytic Leukemia - Summary ... rendering the immune system ... Physical Exam/Signs ... ’s CLL Scoring system ... workup #oncology #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Activation of CD8 T cells ... Autoimmune diseases: SLE ... Lymphohistiocytosis #diagnosis #management ... #treatment #summary ... #rheumatology
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