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diagnosis differential anemia algorithm management hyperkalemia hepatology potassium rheumatology classification high nephrology reactions cirrhosis deficiency dermatology hba1c hemolysis intravascular pathophysiology
Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care TRICC - NEJM 1999 -
Thresholds in Critical ... blood is a liquid ... Blood saves lives ... unnecessary and cause ... #Thresholds #Hematology
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... Elevation == Decreased ... Content • RBC Transfusions ... turnover • Acute blood ... loss • Hemolytic
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... Transfusion Thresholds ... Causes purpura & ... TRALI): Leading cause ... diagnosis #management #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... HUS) • Other: Transfusion ... implicated) - Transfusion ... Extravascular #Causes ... differential #diagnosis #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion ... Causes purpura & ... TRALI): Leading cause ... more likely to cause ... diagnosis #management #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... • Peripheral blood ... Immune mediated hemolysis ... disease, drugs, transfusions ... Diagnosis #Algorithm #causes
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Antibody Autoimmune Hemolytic ... reticulocytes • Hemolysis ... type ± C3d • Blood ... 2) LOOK FOR a cause ... management #treatment #rheumatology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Diagnosis Algorithm Decreased ... WBCs - Decreased ... Bleed • Hemolysis ... #Hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Diagnosis for Hemolytic ... Anemia Intrinsic Causes ... prosthetic valve • Transfusion ... udaygulati #Hemolytic ... classification #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
Mild-to-moderate decrease ... in most cases; ... Platelet count - Decreased ... of Peripheral blood ... Diagnosis #Workup #Hematology
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