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hematology differential algorithm syndrome rheumatology oncology dermatology gastroenterology classification neurology chronic hemolytic infectiousdiseases pulmonary summary blood clinical hemophagocytic hlh leukemia
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Myelofibrosis Infectious ... disorders • Celiac disease ... effect following treatment ... Iron deficiency anemia ... #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... - Differential Diagnosis ... Inflammation, Chronic Infection ... #Algorithm #Causes ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... Thrombocytosis): • Acute infection ... malignancies • Anemia ... #Causes #hematology ... #secondary
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
old, ~10,000 new cases ... cytopenias (usually anemia ... risk-stratification • Risks: infection ... #Management #treatment ... #hematology #oncology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
: • Recurrent infections ... Diagnosis: • Pancytopenia ... Treatment: • Consider ... #diagnosis #management ... #treatment #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... Microangiopathic hemolytic anemia ... Extravascular #Causes ... #hematology #anemia
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
risk secondary ... autoimmune hemolytic anemia ... and M panel Management ... DDX - Other causes ... #diagnosis #management
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... : • Liver disease ... drug induced • Infections ... #hematology
Liver Mass - Differential Diagnosis Algorithm Cystic: • Benign - Simple: Simple
Polycystic Liver Disease ... Benign - Infectious ... CCA, HB - secondary ... #Algorithm #Causes ... #Hepatology
Causes of Localized Lymphadenopathy - Differential Diagnosis Algorithm Cervical: - Anterior • Infection
Causes of Localized ... - Differential Diagnosis ... • Kikuchi Disease ... Tularemia • Secondary ... #Hematology #Oncology
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