13 results
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
of Sickle Cell Disease ... Acute sickle cell hepatic ... hepatomegaly and anemia ... Liver transplant ... Hepatobiliary #hepatology
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
Commonly Observed Laboratory ... Findings in Hepatic ... disease, ALT and ... deficiency - Anemia ... #Hepatology #Laboratory
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Defects, Drugs, Liver ... Defects: Sickle cell anemia ... Hypophostphatemia Laboratory ... Dehydrogenase ↑ - Peripheral ... Differential #Diagnosis #hematology
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Medications - Heparin ... ) • Advanced Liver ... Disease - Alcohol ... Summary #table #comparison ... #diagnosis #hematology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Liver Disease in ... imaging: Hepatic ... #Disease #Pregnancy ... #hepatology #obstetrics ... #hepatitis #comparison
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
inhibitor • Liver ... disease Partial ... elevated in: • Heparin ... Thromboplastin #laboratory ... #hematology #diagnosis
CHA2DS2VASc vs HAS-BLED scores for stroke risk and bleed risk on anticoagulation

C	Congestive Heart Failure	1

H	Hypertension	1

A2	Age >75	2

D	Diabetes Mellitus	1

S2	Stroke,
2 V Vascular disease ... Abnormal renal/liver ... Bleeding history/anemia ... CHADS2VASc #HASBLED #Comparison ... AFib #Diagnosis #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
plateletcount), peripheral ... disease, decrease ... changes), high MCV anemia ... disease), HBsAg ... Causes #Workup #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Bone marrow disease ... - Hemolytic anemia ... deficiency • Liver ... Cholesterol emboli • Septic ... Differential #Diagnosis #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
venipuncture sites Laboratory ... D-Dimer: ↑ • Peripheral ... DIC • Severe Liver ... Disease: - Impaired ... treatment #management #hematology