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differential systemic management signs symptoms erythematosus neurology sle causes myopathy syndrome autoantibodies myopathies sclerosis table treatment antibodies autoimmune comparison diplopia
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
Myositis and Myopathies ... Inclusion Body Myositis ... , +Anti-dsDNA, Myositis ... BostonChiefs #Myositis ... #differential #diagnosis
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
• Transverse myelitis ... pain • Extra-CNS ... positive NMO only): Myositis ... disorders (Systemic lupus ... Manifestations #diagnosis
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
Myositis Specific ... Inclusion Body Myositis ... MithuRheum #Myositis ... MSAs #clinical #diagnosis ... #rheumatology #
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... triad of ILD, myositis ... /full triad at diagnosis ... #Autoimmune #Myositis ... #diagnosis #rheumatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... glycoprotein I (ß2GP), Lupus ... Peptide (CCP) • Myositis ... #diagnosis #associations
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Inclusion body myositis ... Pyomyositis, Lyme myositis ... Malignancy-associated myositis ... anti-RNP - (Myositis ... inclusion body myositis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Diagnosis Manifestations ... anemia 4% - Myositis ... Differential Diagnosis ... Erythematosus #Diagnosis ... #differential #rheumatology
Differential diagnoses for the neuro-ophthalmologic finding of diplopia. Neoplastic: • Intraorbital meningioma • Pituitary adenoma
Differential diagnoses ... for the neuro-ophthalmologic ... pseudotumor • Orbital myositis ... #Differential #Diagnosis ... #Causes #Ophthalmology
Systemic Sclerosis (Scleroderma) Limited - CREST: • Calcinosis • Raynaud phenomenon • Esophageal dysmotility • Sclerodactyly •
involve DIP • Myositis ... #Scleroderma #diagnosis ... signs #symptoms #rheumatology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Normal CK - Myositis ... #Systemic #Lupus ... signs #symptoms #diagnosis
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