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diagnosis algorithm naloxone neurology overdose adies clonidine comparison compylobacterjejuni endocrinology flaccidpalsy floppy gbs guillainbarresyndrome hyperthermic hypotonic immune infant inflammatory iris
Naloxone for Clonidine Overdose Indication: Altered mental status, CNS depression or respiratory depression due to clonidine overdose Dosing:
mental status, CNS ... them may improve CNS ... Naloxone may improve CNS ... Clonidine #Overdose #toxicology ... #management
Short Stature - Differential Diagnosis Algorithm Normal Variant, Normal Puberty Onset (BA = CA) • Familial Short
Short Stature - Differential ... Anorexia Nervosa • CNS ... #ShortStature #Differential ... endocrinology #causes ... #pediatrics
Naloxone - Toxicology Adult starting dose: - 0.4 mg IV/IM/IO/SQ for non-opioid dependent patients - 0.04 mg
opioid-dependent patients Pediatric ... search for other causes ... of CNS depression ... respiratory & CNS ... #Management #Pharmacology
Causes of Hypotonic Infant (Floppy Newborn) - Differential Diagnosis Algorithm Central Nervous System - Decreased LOC, Axial
Causes of Hypotonic ... Floppy Newborn) - Differential ... Hemorrhage • CNS ... Other Congenital Syndromes ... #Peds #Pediatrics
Guillain–Barré syndrome (GBS) (aka: Landry–Guillain–Barré–Strohl syndrome:  Most common cause of acute flaccid paralysis  Rapidly progressive ascending paralysis & areflexia  Autonomic
Guillain–Barré syndrome ...  Most common cause ... Differential diagnosis ... Multiple Sclerosis: CNS ...  Transverse myelitis
Adie's Pupil What? Unknown nature & benign • Regular and mildly dilated pupil (4-6mm); • Light-near dissociaton;
Holmes-Adie Syndrome ... Young females Differential ... Diagnosis: • CN ... dissociation • Other causes ... #Adies #Pupil #PhysicalExam
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
: • 1400 new cases ... that results in CNS ... • Infectious causes ... Myelitis #diagnosis #management ... #neurology #differential
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... Parotid swelling CNS ... nervous system (CNS ... peripheral neuropathy, transverse ... • 8%-27% for CNS
Hyperthermic Toxidromes Five toxidromes may present with overlapping features: hyperthermia, rhabdomyolysis, altered mental status/seizures. • Sympathomimetic -
signaling in the CNS ... • Serotonin Syndrome ... pharmacogenetic disease caused ... table #diagnosis #differential ... #toxicology
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... pleural effusions, CNS ... #Inflammatory #Syndrome ... #Differential # ... Diagnosis #Management
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