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diagnosis differential algorithm causes hematology management clinical workup symptoms nephrology signs pathophysiology hemolytic neurology classification cardiology pulmonary deficiency oncology pediatrics
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Complement Levels - C3 ... , C4 • SLE C3 ... • MCGN type 1 C3 ... ↓ C4 ↓↓ • Cryo ... C3 ↓ C4 ↓↓ •
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Autoimmune Hemolytic Anemia ... IgG positive, C3 ... IgG negative, C3 ... Autoimmune #Hemolytic #Anemia
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Autoimmune Hemolytic Anemia ... Autoimmune Hemolytic Anemia ... positive for IgG +/- C3 ... Autoimmune Hemolytic Anemia ... Coombs Positive for C3
Differential Diagnosis of Anemias #Diagnosis #IM #Honc #Anemia #Differential #Iron #Algorithm #Microcytic #Macrocytic #Normocytic #Ddxof
Differential Diagnosis of Anemias ... Diagnosis #IM #Honc #Anemia
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Algorithm Signs of anemia ... Autoimmune Hemolytic Anemias ... Alloimmune Hemolytic Anemias ... #Hemolytic #Anemias
Glomerulonephritis - Differential Diagnosis Framework ANCA: • C-ANCA: GPA (Wegener's) • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
Mediated: • ↓C3 ... Cryoglobulinemia • Normal C3
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
NEUROLOGIC - HEMOLYTIC ANEMIA ... Low complement (C3 ... absence of hemolytic anemia
Herpes Zoster C3 Distribution: Dermatomally distributed vesicles, many of which have coalesced, in patient with HZV
Herpes Zoster C3 ... HZV #Dermatomal #C3
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... Chronic disease anemia ... Sideroblastic anemia ... iron deficiency anemia ... Autoimmune hemolytic anemia
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
breakdown • Anaemia ... Hemolysis #Hemolytic #Anemia
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