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differential causes gastroenterology rheumatology treatment algorithm classification coagulation comparison pathophysiology summary syndrome aflp anemia arterial bleeding blood bruising cirrhosis hemolysis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... coagulation (DIC ... cold agglutin disease ... #differential #diagnosis ... #hematology #anemia
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
- Differential Diagnosis ... - Disseminated intravascular ... APLS:PLT ↓ HEMATOLOGIC ... #Differential #Diagnosis ... #clots #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
, Liver diseases ... , Disseminated intravascular ... coagulopathy (DIC ... Morphology #Atlas #key #diagnosis ... #differential #hematology
End Stage Liver Disease (Cirrhosis) - Complications • Ascites • Esophageal Varices • Hepatic
End Stage Liver ... Disease (Cirrhosis ... Complications #diagnosis ... #management #summary ... #hepatology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Extrinsic Causes: • Liver ... disease • Hypersplenism ... IVIG infusion Intravascular ... MAHA: TTP, HUS, DIC ... classification #hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
- Differential Diagnosis ... Iatrogenic) • Liver ... • Disseminated Intravascular ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
disease, liver ... Hepatitis Procedures Management ... Failure #Cirrhosis #Hepatology ... gastroenterology #management ... #diagnosis
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) Prothrombin Time (PT) - Often Elevated in: • Vitamin
inhibitor • Liver ... disease Partial ... elevated in: • DIC ... Thromboplastin #laboratory #hematology ... #diagnosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Severe Liver ... Disease: - Impaired ... #Coagulation #diagnosis ... causes #treatment #management ... #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... MAHA: TTP, HUS, DIC ... Defects, Drugs, Liver ... Disease, PNH ... #hematology
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