1099 results
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... -> Release of DNA ... Syndrome #TLS #Pathophysiology
Melanoma Pathogenesis

Environmental exposure (UV light) + genetic susceptibility (CDKN2A, CDK4, MC1R, BRAF, p16/ARF genes) → accumulation
genes and impair DNA ... #Pathophysiology
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
Biliary Cirrhosis - Pathophysiology ... female-predominant disease), DNA ... relative with PBC Pathophysiology ... Biliary #Cirrhosis #Pathophysiology
Retroviral Infections: Mechanisms of Oncogenesis
Note: A retrovirus is an RNA virus that uses reverse transcriptase to
retrovirus is an RNA ... to synthesize DNA ... from the RNA before ... incorporating the new DNA ... #oncogenesis #pathophysiology
Hyperuricemia: Pathogenesis and Complications

 - Hypercalcemia (due to diseases like Sarcoidosis and Hyperparathyroidism) -> Accumulation of
Incr Breakdown of DNA ... Hyperuricemia #Pathophysiology
The Inhibited Pathway caused by N2O, leading to a decrease in the active form of Vitamin
production of DNA ... , RNA, and myelin ... #Pathophysiology
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
• Lupus (SLE): ANA ... double-stranded DNA ... Anti-centromere, Scl-70 (DNA ... topoisomerase I), RNA
Pathophysiology and Effects of Insulin Deficiency

#Insulin #Deficiency #DKA #Ketoacidosis #Diabetes #Pathophysiology #Endocrinology
Pathophysiology ... Insulin #Deficiency #DKA ... Ketoacidosis #Diabetes #Pathophysiology
Rifamycins - Antibiotics Class Overview

Include Rifampin, Rifaximin, Rifapentine, Rifabutin.

Mechanism: Inhibits bacterial DNA-dependent RNA polymerase (unique mechanism).
Inhibits bacterial DNA-dependent ... RNA polymerase
Pathogenesis and Pathophysiology of Diabetic Ketoacidosis (DKA)

DKA is a result of an absolute or relative insulin
Pathogenesis and Pathophysiology ... Ketoacidosis (DKA ... ) DKA is a result ... details of the pathophysiology ... #Pathophysiology